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What diuretic is used for heart failure? Knowledge of the pharmacology of diuretics is essential in understanding their function in the management of heart failure. The current available loop diuretics are furosemide, torsemide, bumetanide, and ethacrynic acid. They inhibit the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle.
How long does it take for hydrochlorothiazide to lower blood pressure? Mechanism of Action. Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid. Pharmacological effects begin in about 2 hours after an oral dose, peaks in 4 hours, and lasts for about 6 to 12 hours.