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Well-designed small studies without the statistical power to resolve clinical disagreement, or disturb “clinical equipoise” (see further), cannot be considered to be a high level of evidence of a null effect or superior or inferior efficacy.

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Sometimes anti-thyroid drugs are used in conjunction with radioactive iodine, a therapy that reduces the production of thyroid hormone.

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Iron supplementation during pregnancy.

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In some cases, if the nodule is accompanied by hyperthyroidism, radioactive iodine (RAI) is used, to shrink the nodule and the thyroid gland.

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Natural desiccated thyroid was the only thyroid drug available in the early 1900s, under the brand name Armour Thyroid, until levothyroxine was introduced in the 1950s.

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